Year

Publications

  1. Kitayama N, Nakashima C, Sawada T, Tanaka N, Hagiwara M, Otsuka A, Kabashima K. (2025) Targeting PAR-2 in atopic dermatitis: Preclinical evaluation of the novel inhibitor E6795. Biochem Biophys Res Commun. 782:152590. doi: 10.1016/j.bbrc.2025.152590.
  2. Toyomoto M, Kurihara T, Nakagawa T, Inoue A, Kimura R, Kii I, Sawada T, Ogihara T, Nagayasu K, Kishi T, Onogi H, Im D, Asada H, Iwata S, Taguchi J, Sumida Y, Yoshida S, Aoki J, Hosoya T, Hagiwara M. (2025) Discovery and development of an oral analgesic targeting the α2B adrenoceptor. Proc Natl Acad Sci U S A. 122(32):e2500006122. doi: 10.1073/pnas.2500006122.
  3. Yokoyama Y, Toyomoto M, Tanaka N, Tanaka S, Nishikawa S, Kayawake H, Morimura Y, Oda H, Yamauchi M, Yamamoto M, Chen-Yoshikawa TF, Hagiwara M, Date H. (2025) The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model. Sci Rep. 15(1):15217. doi: 10.1038/s41598-025-99851-7.
  4. Lee SA, Ogawa M, Saito Y, Shimazaki R, Awaya T, Hosokawa M, Kurosawa R, Ohara H, Takeuchi A, Hayashi S, Goto YI, Hagiwara M, Nishino I, Noguchi S. (2025) Substitutions of nucleotides at the 3′ ends of COL6A1/2/3 exons induce exon skipping associated with collagen VI-related muscular dystrophies and therapeutic strategies. Genet Med. 101431. doi: 10.1016/j.gim.2025.101431.
  5. Awaya T, Ajiro M, Kobayashi H, Sawada T, Gotanda K, Noji T, Takemoto N, Iida K, Saito MK, Niu DM, Hagiwara M. (2025) Invention of an oral medication for cardiac Fabry disease caused by RNA mis-splicing. Sci Adv. 11(15):eadt9695. doi: 10.1126/sciadv.adt9695.
  6. Iida K, Ajiro M, Nakano-Kobayashi A, Muramoto Y, Takenaga T, Denawa M, Kurosawa R, Noda T, Hagiwara M. (2025) Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection. BMC Biol. 23(1):60. doi: 10.1186/s12915-025-02173-3.
  7. Shimazaki R, Saito Y, Awaya T, Minami N, Kurosawa R, Hosokawa M, Ohara H, Hayashi S, Takeuchi A, Hagiwara M, Hayashi YK, Noguchi S, Nishino I. (2025) Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy. Orphanet J Rare Dis. 20(1):1. doi: 10.1186/s13023-024-03521-2.
  8. Ono M, Toyomoto M, Yamauchi M, Hagiwara M. (2024) Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release. Cell Chem Biol. 31(12):2085-2095.e4. doi: 10.1016/j.chembiol.2024.11.003.
  9. Yano N, Chong PF, Kojima KK, Miyoshi T, Luqmen-Fatah A, Kimura Y, Kora K, Kayaki T, Maizuru K, Hayashi T, Yokoyama A, Ajiro M, Hagiwara M, Kondo T, Kira R, Takita J, Yoshida T. (2024) Long-read sequencing identifies an SVA_D retrotransposon insertion deep within the intron of ATP7A as a novel cause of occipital horn syndrome. J Med Genet. jmg-2024-110056. doi: 10.1136/jmg-2024-110056.
  10. Ohnishi Y, Masui A, Suezawa T, Mikawa R, Hirai T, Hagiwara M, Gotoh S. (2024) Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells. Stem Cell Reports. S2213-6711(24)00047-X. doi: 10.1016/j.stemcr.2024.02.009.
  11. Yamada M, Maeta K, Suzuki H, Kurosawa R, Takenouchi T, Awaya T, Ajiro M, Takeuchi A, Nishio H, Hagiwara M, Miya F, Matsuo M, Kosaki K. (2024) Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration. Sci Rep. 14(1):6506. doi: 10.1038/s41598-024-56704-z.
  12. Hirai M, Ikeda A, Kato T, Ikeda T, Asada K, Hakuno Y, Matsushima K, Awaya T, Okazaki S, Kato T, Heike T, Hagiwara M, Yamagata T, Tomiwa K, Kimura R. (2024) Comparison of the Sensory Profile Among Autistic Individuals and Individuals with Williams Syndrome. J Autism Dev Disord. doi: 10.1007/s10803-023-06205-1.
  13. Kurosawa R, Iida K, Ajiro M, Awaya T, Yamada M, Kosaki K, Hagiwara M. (2023) PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing. BMC Genomics. 24(1):601. doi: 10.1186/s12864-023-09645-2.
  14. Sato JI, Onogi H, Nomura N, Hagiwara M, Inouye S. (2023) Bioluminescent immunoassay for serine/threonine protein kinase activity using an aequorin-labeled monoclonal antibody and a synthetic peptide as a substrate. Biochem Biophys Res Commun. 681:180-185. doi: 10.1016/j.bbrc.2023.09.062.
  15. Hosokawa M, Mikawa R, Hagiwara A, Okuno Y, Awaya T, Yamamoto Y, Takahashi S, Yamaki H, Osawa M, Setoguchi Y, Saito MK, Abe S, Hirai T, Gotoh S, Hagiwara M. (2023) Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC. iScience. 26(10):107731. doi: 10.1016/j.isci.2023.107731.
  16. Nakano-Kobayashi A, Canela A, Yoshihara T, Hagiwara M. (2023) Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway. Proc Natl Acad Sci USA. 120(33):e2303809120. doi: 10.1073/pnas.2303809120.
  17. Ohara H, Hosokawa M, Awaya T, Hagiwara A, Kurosawa R, Sako Y, Ogawa M, Ogasawara M, Noguchi S, Goto Y, Takahashi R, Nishino I, Hagiwara M. (2023) Branchpoints as potential targets of exon-skipping therapies for genetic disorders. Mol Ther Nucleic Acids. 33:404-412. doi: 10.1016/j.omtn.2023.07.011.
  18. Nagai T, Terada N, Fujii M, Nagata Y, Nakahara K, Mukai S, Okasho K, Kamiyama Y, Akamatsu S, Kobayashi T, Iida K, Denawa M, Hagiwara M, Inoue T, Ogawa O, Kamoto T. (2023) Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models. Cancer Rep (Hoboken). 6(2):e1701. doi: 10.1002/cnr2.1701.
  19. Sakamoto T, Ajiro M, Watanabe A, Matsushima S, Ueda K, Hagiwara M. (2023) Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy. BMC Cancer. 23(1):71. doi: 10.1186/s12885-023-10540-y.
  20. Matsushima S, Ajiro M, Iida K, Chamoto K, Honjo T, Hagiwara M. (2022) Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer. Sci Transl Med. 14(673):eabn6056. doi: 10.1126/scitranslmed.abn6056.
  21. Kanemitsu E, Zhao X, Iwaisako K, Inoue A, Takeuchi A, Yagi S, Masumoto H, Ohara H, Hosokawa M, Awaya T, Aoki J, Hatano E, Uemoto S, Hagiwara M. (2022) Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation. Transl Res. 255:26-36. doi: 10.1016/j.trsl.2022.11.003.
  22. Tamai K, Sakai K, Yamaki H, Moriguchi K, Igura K, Maehana S, Suezawa T, Takehara K, Hagiwara M, Hirai T, Gotoh S. (2022) iPSC-derived mesenchymal cells that support alveolar organoid development. Cell Rep Methods. 2(10):100314. doi: 10.1016/j.crmeth.2022.100314.
  23. Hirai M, Asada K, Kato T, Ikeda T, Hakuno Y, Ikeda A, Matsushima K, Awaya T, Okazaki S, Kato T, Funabiki Y, Murai T, Heike T, Hagiwara M, Yamagata T, Tomiwa K, Kimura R. (2022) Comparison of the Social Responsiveness Scale-2 among Individuals with Autism Spectrum Disorder and Williams Syndrome in Japan. J Autism Dev Disord. doi: 10.1007/s10803-022-05740-7. doi: 10.1007/s10803-022-05740-7.
  24. Takashima Y, Murata A, Iida K, Sugai A, Hagiwara M, Nakatani K. (2022) Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding. ACS Chem Biol. 17(10):2817-2827. doi: 10.1021/acschembio.2c00452.
  25. Okubo M, Noguchi S, Awaya T, Hosokawa M, Tsukui N, Ogawa M, Hayashi S, Komaki H, Mori-Yoshimura M, Oya Y, Takahashi Y, Fukuyama T, Funato M, Hosokawa Y, Kinoshita S, Matsumura T, Nakamura S, Oshiro A, Terashima H, Nagasawa T, Sato T, Shimada Y, Tokita Y, Hagiwara M, Ogata K, Nishino I. (2022) RNA-seq analysis, targeted long-read sequencing and in silico prediction to unravel pathogenic intronic events and complicated splicing abnormalities in dystrophinopathy. Hum Genet. 142(1):59-71. doi: 10.1007/s00439-022-02485-2.
  26. Okazaki S, Kimura R, Otsuka I, Tomiwa K, Funabiki Y, Hagiwara M, Murai T, Hishimoto A. (2022) Epigenetic aging in Williams syndrome. J Child Psychol Psychiatry. 63(12):1553-1562. doi: 10.1111/jcpp.13613.
  27. Nomura T, Sumi E, Egawa G, Nakajima S, Toichi E, Inoue N, Shibuya M, Okamoto N, Mitsuishi T, Uozumi R, Tada H, Nakagawa T, Kusuba N, Okuno A, Shimizuhira C, Ishikawa M, Tanaka S, Hagiwara M, Kabashima K. (2021) Safety and Efficacy of FIT039 for Verruca Vulgaris: A Placebo-Controlled, Phase I/II Randomized Controlled Trial. JID Innov. 1(3):100026. doi: 10.1016/j.xjidi.2021.100026.
  28. Suezawa T, Kanagaki S, Moriguchi K, Masui A, Nakao K, Toyomoto M, Tamai K, Mikawa R, Hirai T, Murakami K, Hagiwara M, Gotoh S. (2021) Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids. Stem Cell Reports. 16(12):2973-2987. doi: 10.1016/j.stemcr.2021.10.015.
  29. Suezawa T, Kanagaki S, Korogi Y, Nakao K, Hirai T, Murakami K, Hagiwara M, Gotoh S. (2021) Modeling of lung phenotype of Hermansky-Pudlak syndrome type I using patient-specific iPSCs. Respir Res. 22(1):284. doi: 10.1186/s12931-021-01877-8.
  30. Ikeo S, Yamamoto Y, Ikeda K, Sone N, Korogi Y, Tomiyama L, Matsumoto H, Hirai T, Hagiwara M, Gotoh S. (2021) Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo. Biomaterials. 276:121031. doi: 10.1016/j.biomaterials.2021.121031.
  31. Ajiro M, Awaya T, Kim YJ, Iida K, Denawa M, Tanaka N, Kurosawa R, Matsushima S, Shibata S, Sakamoto T, Studer L, Krainer AR, Hagiwara M. (2021) Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nat Commun. 12(1):4507. doi: 10.1038/s41467-021-24705-5.
  32. Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa YS, Gotoh S. (2021) Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology. Sci Transl Med. 13(601):eabb1298. doi: 10.1126/scitranslmed.abb1298.
  33. Maeda S, Shiimura Y, Asada H, Hirata K, Luo F, Nagano E, Tanaka N, Toyomoto M, Inoue A, Aoki J, Iwata S, Hagiwara M. (2021) Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias. Sci Adv. 7(24):eabf5325. doi: 10.1126/sciadv.abf5325.
  34. Uzor S, Porazinski SR, Li L, Clark B, Ajiro M, Iida K, Hagiwara M, Alqasem AA, Perks CM, Wilson ID, Oltean S, Ladomery MR. (2021) CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer. Sci Rep. 11(1):7963. doi: 10.1038/s41598-021-86908-6.
  35. Toyomoto M, Inoue A, Iida K, Denawa M, Kii I, Ngako Kadji FM, Kishi T, Im D, Shimamura T, Onogi H, Yoshida S, Iawata S, Aoki J, Hosoya T, Hagiwara M. (2021) S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation. Cell Chem Biol. S2451-9456(21)00004-0. doi: 10.1016/j.chembiol.2021.01.004.
  36. Kanagaki S, Suezawa T, Moriguchi K, Nakao K, Toyomoto M, Yamamoto Y, Murakami K, Hagiwara M, Gotoh S. (2021) Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells. Am J Respir Cell Mol Biol. 64(4):504-514. doi: 10.1165/rcmb.2020-0119OC.
  37. Kanagaki S, Ikeo S, Suezawa T, Yamamoto Y, Seki M, Hirai T, Hagiwara M, Suzuki Y, Gotoh S. (2021) Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition. Stem Cells. 39(2):156-169. doi: 10.1002/stem.3302.
  38. Nakano-Kobayashi A, Fukumoto A, Morizane A, Nguyen DT, Le TM, Hashida K, Hosoya T, Takahashi R, Takahashi J, Hori O, Hagiwara M. (2020) Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation. Sci Adv. 6(46):eabc1428. doi: 10.1126/sciadv.abc1428.
  39. Shibata S, Ajiro M, Hagiwara M. (2020) Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion. Cell Chem Biol. 27(12):1472-1482.e6. doi: 10.1016/j.chembiol.2020.08.013.
  40. Takeuchi A, Takahashi Y, Iida K, Hosokawa M, Irie K, Ito M, Brown JB, Ohno K, Nakashima K, Hagiwara M. (2020) Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage. Stem Cell Reports. 15(4):883-897. doi: 10.1016/j.stemcr.2020.08.010.
  41. Iida K, Hagiwara M, Takeuchi A. (2020) Multilateral bioinformatics analyses reveal the function-oriented target specificities and recognition of the RNA-binding protein SFPQ. iScience. 23(7):101325. doi: 10.1016/j.isci.2020.101325.
  42. Kawamura H, Nojima T, Oshiro-Ideue T, Kataoka N, Hagiwara M. (2020) RNA binding activity of HSV-2 ICP27 protein. RNA & DISEASE. 7: e1165. doi: 10.14800/rd.1165.
  43. Suzuki S, Kimura R, Maegawa S, Nakata M and Hagiwara M. (2020) Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish. Mol Brain. 13(1):70. doi: 10.1186/s13041-020-00614-4.
  44. Kimura R, Lardenoije R, Tomiwa K, Funabiki Y, Nakata M, Suzuki S, Awaya T, Kato T, Okazaki S, Murai T, Heike T, Rutten BPF, Hagiwara M. (2020) Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome. Neuropsychopharmacology. 45(10):1627-1636. doi: 10.1038/s41386-020-0675-2.
  45. Kimura R, Tomiwa K, Inoue R, Suzuki S, Nakata M, Awaya T, Kato T, Okazaki S, Heike T, Hagiwara M. (2020) Dysregulation of the oxytocin receptor gene in Williams syndrome. Psychoneuroendocrinology. 115:104631. doi: 10.1016/j.psyneuen.2020.104631.
  46. Kawashima M, Tokiwa M, Nishimura T, Kawata Y, Sugimoto M, Kataoka TR, Sakurai T, Iwaisako K, Suzuki E, Hagiwara M, Harris AL, Toi M. (2020) High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer. Br J Cancer. 122(2):245-257. doi: 10.1038/s41416-019-0662-8.
  47. Nakata M, Kimura R, Funabiki Y, Awaya T, Murai T, Hagiwara M. (2019) MicroRNA profiling in adults with high-functioning autism spectrum disorder. Mol Brain. 12(1):82. doi: 10.1186/s13041-019-0508-6.
  48. Kimura R, Nakata M, Funabiki Y, Suzuki S, Awaya T, Murai T, Hagiwara M. (2019) An epigenetic biomarker for adult high-functioning autism spectrum disorder. Sci Rep. 9(1):13662. doi: 10.1038/s41598-019-50250-9.
  49. Nomura T, Sumi E, Egawa G, Nakajima S, Toichi E, Uozumi R, Tada H, Nakagawa T, Hagiwara M, Kabashima K. (2019) The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial. Trials. 20(1):489. doi: 10.1186/s13063-019-3570-6.
  50. Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M. (2019) Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy. iScience. 13:229-242. doi: 10.1016/j.isci.2019.02.023.
  51. Ichisima J, Suzuki NM, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito MK. (2019) Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. J Hum Genet. 64(5):445-458. doi: 10.1038/s10038-019-0574-8.
  52. Korogi Y, Gotoh S, Ikeo S, Yamamoto Y, Sone N, Tamai K, Konishi S, Nagasaki T, Matsumoto H, Ito I, Chen-Yoshikawa TF, Date H, Hagiwara M, Asaka I, Hotta A, Mishima M, Hirai T. (2019) In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. Stem Cell Reports. 12(3):431-440. doi: 10.1016/j.stemcr.2019.01.014.
  53. Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T. (2019) Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency. J Clin Invest. 129(2):583-597. doi: 10.1172/JCI124011.
  54. Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, Geschwind DH, Hagiwara M. (2019) Integrative network analysis reveals biological pathways associated with Williams syndrome. J Child Psychol Psychiatry. 60(5):585-598. doi: 10.1111/jcpp.12999.
  55. Sumi E, Nomura T, Asada R, Uozumi R, Tada H, Amino Y, Sawada T, Yonezawa A, Hagiwara M, Kabashima K. (2019) Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. Clin Drug Investig. 39(1):55-61. doi: 10.1007/s40261-018-0712-7.
  56. Kimura R, Ishii Y, Tomiwa K, Awaya T, Nakata M, Kato T, Okazaki S, Heike T, Hagiwara M. (2018) Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma. Front Genet. 9:368. doi: 10.3389/fgene.2018.00368.
  57. Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M. (2018) Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. Biochem Biophys Res Commun. 503(2):544-549. doi: 10.1016/j.bbrc.2018.05.153.
  58. Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, Hagiwara M. (2018) Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell Rep. 23(5):1326-1341. doi: 10.1016/j.celrep.2018.03.141.
  59. Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M. (2018) CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. Clin Cancer Res. 24(18):4518-4528. doi: 10.1158/1078-0432.CCR-17-3119.
  60. Yamada S, Nagai M, Hagiwara M. (2018) The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine. Anat Rec (Hoboken). 301(6):947-950. doi: 10.1002/ar.23786.
  61. Yoshida S, Kanno K, Kii I, Misawa Y, Hagiwara M, Hosoya T. (2018) Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions. Chem Commun (Camb). 54(30):3705-3708. doi: 10.1039/c8cc01195h.
  62. Wang DO, Ninomiya K, Mori C, Koyama A, Haan M, Kitabatake M, Hagiwara M, Chida K, Takahashi SI, Ohno M, Kataoka N. (2017) Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes. Front Mol Biosci. 4:93. doi: 10.3389/fmolb.2017.00093.
  63. Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M. (2017) Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. Proc Natl Acad Sci USA. 114(38):10268-10273. doi: 10.1073/pnas.1704143114.
  64. Matsumoto S, Iida K, Murata A, Denawa M, Hagiwara M, Nakatani K. (2017) Synthetic ligand promotes gene expression by affecting GC sequence in promoter. Bioorg Med Chem Lett. 27(15):3391-3394. doi: 10.1016/j.bmcl.2017.06.006.
  65. Ohe K, Yoshida M, Nakano-Kobayashi A, Hosokawa M, Sako Y, Sakuma M, Okuno Y, Usui T, Ninomiya K, Nojima T, Kataoka N, Hagiwara M. (2017) RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in the IKBKAP gene of familial dysautonomia. RNA. 23(9):1393-1403. doi: 10.1261/rna.059428.116.
  66. Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M. (2017) In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate. EMBO J. 36(13):1888-1907. doi: 10.15252/embj.201695862.
  67. Kawaguchi K, Suzuki E, Nishie M, Kii I, Kataoka TR, Hirata M, Inoue M, Pu F, Iwaisako K, Tsuda M, Yamaguchi A, Haga H, Hagiwara M, Toi M. (2017) Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity. Cancer Immunol Immunother. 66(9):1131-1142. doi: 10.1007/s00262-017-2002-2.
  68. Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M. (2017) Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Sci Rep. 7:46126. doi: 10.1038/srep46126.
  69. Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M. (2017) Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. Sci Rep. 7:41710. doi: 10.1038/srep41710.
  70. Nguyen BN, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M. (2016) Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression. J Med Virol. 89(7):1224-1234. doi: 10.1002/jmv.24739.
  71. Candeias MM, Hagiwara M, Matsuda M. (2016) Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. EMBO Rep. 17(11):1542-1551. doi: 10.15252/embr.201541956.
  72. Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K. (2016) Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Antiviral Res. 133:156-164. doi: 10.1016/j.antiviral.2016.08.008.
  73. Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M. (2016) Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 7:11391. doi: 10.1038/ncomms11391.
  74. Sakuma M, Iida K, Hagiwara M. (2015) Deciphering targeting rules of splicing modulator compounds: case of TG003. BMC Mol Biol. 16:16. doi: 10.1186/s12867-015-0044-6.
  75. Okamoto M, Hidaka A, Toyama M, Hosoya T, Yamamoto M, Hagiwara M, Baba M. (2015) Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039. Antiviral Res. 123:1-4. doi: 10.1016/j.antiviral.2015.08.012.
  76. Ohnishi T, Yanazawa M, Sasahara T, Kitamura Y, Hiroaki H, Fukazawa Y, Kii I, Nishiyama T, Kakita A, Takeda H, Takeuchi A, Arai Y, Ito A, Komura H, Hirao H, Satomura K, Inoue M, Muramatsu S, Matsui K, Tada M, Sato M, Saijo E, Shigemitsu Y, Sakai S, Umetsu Y, Goda N, Takino N, Takahashi H, Hagiwara M, Sawasaki T, Iwasaki G, Nakamura Y, Nabeshima Y, Teplow DB, Hoshi M. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc Natl Acad Sci USA. 112(32):E4465-4474. doi: 10.1073/pnas.1421182112.
  77. Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, Hagiwara M. (2015) Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Sci Rep. 5:12728. doi: 10.1038/srep12728.
  78. Masaki S, Kii I, Sumida Y, Kato-Sumida T, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N, Hosoya T, Hagiwara M. (2015) Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis. Bioorg Med Chem. 23(15):4434-4441. doi: 10.1016/j.bmc.2015.06.018.
  79. Morooka S, Hoshina M, Kii I, Okabe T, Kojima H, Inoue N, Okuno Y, Denawa M, Yoshida S, Fukuhara J, Ninomiya K, Ikura T, Furuya T, Nagano T, Noda K, Ishida S, Hosoya T, Ito N, Yoshimura N, Hagiwara M. (2015) Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice. Mol Pharmacol. 88(2):316-325. doi: 10.1124/mol.114.097345.
  80. Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M. (2015) Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc Natl Acad Sci USA. 112(9):2764-2769. doi: 10.1073/pnas.1415525112.
  81. Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Güntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, Muto Y. (2014) RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing. Nat Struct Mol Biol. 21(9):778-786. doi: 10.1038/nsmb.2870.
  82. Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M. (2014) CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. J Clin Invest. 124(8):3479-3488. doi: 10.1172/JCI73805.
  83. Kurihara T, Sakurai E, Toyomoto M, Kii I, Kawamoto D, Asada T, Tanabe T, Yoshimura M, Hagiwara M, Miyata A. (2014) Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain. 10:17. doi: 10.1186/1744-8069-10-17.
  84. Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO. (2013) Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Invest Ophthalmol Vis Sci. 54(9):6052-6062. doi: 10.1167/iovs.13-12422.
  85. Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P. (2013) Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J Clin Invest. 123(6):2475-2487. doi: 10.1172/JCI63623.
  86. Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S (2013) Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization. Mol Vis. 19:536-543.
  87. Kuroyanagi H, Watanabe Y, Suzuki Y, Hagiwara M. (2013) Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans. Nucleic Acids Res. 41(7):4015-4025. doi: 10.1093/nar/gkt097.
  88. Kuroyanagi H, Watanabe Y, Hagiwara M. (2013) CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet. 9(2):e1003337. doi: 10.1371/journal.pgen.1003337.
  89. Kataoka N, Dobashi I, Hagiwara M, Ohno M. (2013) hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity. Sci Rep. 3:1090. doi: 10.1038/srep01090.
  90. Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H (2012) Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans. PLoS Genet. 8(10):e1002991. doi: 10.1371/journal.pgen.1002991.
  91. Saitoh N, Sakamoto C, Hagiwara M, Agredano-Moreno LT, Jiménez-García LF, Nakao M. (2012) The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2. Mol Biol Cell. 23(6):1115-1128. doi: 10.1091/mbc.E11-09-0783.
  92. Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M. (2012) I Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication. Antimicrob Agents Chemother, 56(3):1315-1323. doi: 10.1128/AAC.05764-11.
  93. Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR. (2011) WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell. 20(6):768-780. doi: 10.1016/j.ccr.2011.10.016.
  94. Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M. (2011) Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA. Sci Rep. 1:92. doi: 10.1038/srep00092.
  95. Ninomiya K, Kataoka N, Hagiwara M. (2011) Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor. J Cell Biol. 195(1):27-40. doi: 10.1083/jcb.201107093.
  96. Anwar A, Hosoya T, Leong KM, Onogi H, Okuno Y, Hiramatsu T, Koyama H, Suzuki M, Hagiwara M, Garcia-Blanco MA. (2011) The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. PLoS One. 6(8):e23246. doi: 10.1371/journal.pone.0023246.
  97. Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP. (2011) Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 54(12):4172-4186. doi: 10.1021/jm200274d.
  98. Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano H, Ota M, Itoh K, Hagiwara M, Matsuo M. (2011) Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nat Commun. 2:308. doi: 10.1038/ncomms1306.
  99. Sims-Lucas S, Cusack B, Baust J, Eswarakumar VP, Masatoshi H, Takeuchi A, Bates CM. (2011) Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn. 240(1):240-249. doi: 10.1002/dvdy.22501.
  100. Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M. (2010) Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat Commun. 1: 86. doi: 10.1038/ncomms1090.
  101. Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M. (2010) Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Antimicrob Agents Chemother. 54(8):3179-3186. doi: 10.1128/AAC.00113-10.
  102. Kii I, Shiraishi A, Hiramatsu T, Matsushita T, Uekusa H, Yoshida S, Yamamoto M, Kudo A, Hagiwara M, Hosoya T. (2010) Strain-promoted double-click reaction for chemical modification of azido-biomolecules. Org Biomol Chem. 8(18):4051-4055. doi: 10.1039/c0ob00003e.
  103. Takeuchi A, Hosokawa M, Nojima T, Hagiwara M. (2010) Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PLoS One. 5(6):e10946. doi: 10.1371/journal.pone.0010946.
  104. Kuroyanagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M. (2010) Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans. Nat Protoc. 5(9):1495-1517. doi: 10.1038/nprot.2010.107.
  105. Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO. (2010) Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem. 285(8):5532-5540. doi: 10.1074/jbc.M109.074930.
  106. Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N, Hagiwara M. (2009) Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. Nucleic Acids Res. 37(19):6515-6527. doi: 10.1093/nar/gkp633.
  107. Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR. (2009) Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCbetaII messenger ribonucleic acid. Endocrinology. 150(5):2087-2097. doi: 10.1210/en.2008-0818.
  108. Yomoda J, Muraki M, Kataoka N, Hosoya T, Suzuki M, Hagiwara M, Kimura H. (2008) Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells. 13(3):233-244. doi: 10.1111/j.1365-2443.2008.01163.x.
  109. Ohno G, Hagiwara M, Kuroyanagi H. (2008) STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes Dev. 22(3):360-374. doi: 10.1101/gad.1620608.
  110. Kuroyanagi H, Ohno G, Mitani S, Hagiwara M. (2007) The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol Cell Biol. 27(24):8612-8621. doi: 10.1128/MCB.01508-07.
  111. Ideue T, Sasaki YT, Hagiwara M, Hirose T. (2007) Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes Dev. 21(16):1993-1998. doi: 10.1101/gad.1557907.
  112. Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M. (2007) Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol. 3(9):576-583. doi: 10.1038/nchembio.2007.18.
  113. Nojima T, Hirose T, Kimura H, Hagiwara M. (2007) The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. J Biol Chem. 282(21):15645-15651. doi: 10.1074/jbc.M700629200.
  114. Aida T, Konishi A, Hagiwara M, Hashimoto K. (2007) Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip. Nat Biotechnol. 25(5):533-535. doi: 10.1038/nbt0507-533.
  115. Kimura H, Takizawa N, Allemand E, Hori T, Iborra FJ, Nozaki N, Muraki M, Hagiwara M, Krainer AR, Fukagawa T, Okawa K. (2006) A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B. J Cell Biol. 175(3):389-400. doi: 10.1038/nbt0507-533.
  116. Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M. (2006) Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Nat Methods. 3(11):909-915. doi: 10.1038/nbt0507-533.
  117. Wada K, Howard JT, McConnell P, Whitney O, Lints T, Rivas MV, Horita H, Patterson MA, White SA, Scharff C, Haesler S, Zhao S, Sakaguchi H, Hagiwara M, Shiraki T, Hirozane-Kishikawa T, Skene P, Hayashizaki Y, Carninci P, Jarvis ED. (2006) A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci USA. 103(41):15212-15217. doi: 10.1073/pnas.0607098103.
  118. Hirose T, Ideue T, Nagai M, Hagiwara M, Shu MD, Steitz JA. (2006) A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. Mol Cell. 23(5):673-684. doi: 10.1016/j.molcel.2006.07.011.
  119. Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M. (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci USA. 103(30):11329-11333. doi: 10.1073/pnas.0604616103.
  120. Ohki N, Hagiwara M. (2005) Bio-Object, a stochastic simulator for post-transcriptional regulation. Bioinformatics. 21(10):2478-2487. doi: 10.1093/bioinformatics/bti316.
  121. Wada K, Sakaguchi H, Jarvis ED, Hagiwara M. (2004) Differential expression of glutamate receptors in avian neural pathways for learned vocalization. J Comp Neurol. 476(1):44-64. doi: 10.1002/cne.20201.
  122. Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M. (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 279(23):24246-24254. doi: 10.1074/jbc.M314298200.
  123. Takano M, Koyama Y, Ito H, Hoshino S, Onogi H, Hagiwara M, Furukawa K, Horigome T. (2004) Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. J Biol Chem. 279(13):13265-13271. doi: 10.1074/jbc.M308854200.
  124. Inoue K, Zama T, Kamimoto T, Aoki R, Ikeda Y, Kimura H, Hagiwara M. (2004) TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells. Genes Cells. 9(1):59-70. doi: 10.1111/j.1356-9597.2004.00707.x.
  125. Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K. (2003) Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Biochem Biophys Res Commun. 301(2):324-329. doi: 10.1016/s0006-291x(02)03017-6.
  126. Suzuki H, Wu J, Hossain K, Ohhata T, Du J, Akhand AA, Hayakawa A, Kimura H, Hagiwara M, Nakashima I. (2003) Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. FASEB J. 17(11):1538-1540. doi: 10.1096/fj.02-0869fje.
  127. Katsu R, Onogi H, Wada K, Kawaguchi K, Hagiwara M. (2002) Novel SR-related protein Clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. J Biol Chem. 277(46):44220-44228. doi: 10.1074/jbc.M206504200.
  128. Suzuki T, Yamakuni T, Hagiwara M, Ichinose H. (2002) Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. J Biol Chem. 277(43):40768-40774. doi: 10.1074/jbc.M206043200.
  129. Kimura Y, Corcoran EE, Eto K, Gengyo-Ando K, Muramatsu MA, Kobayashi R, Freedman JH, Mitani S, Hagiwara M, Means AR, Tokumitsu H. (2002) A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep. 3(10):962-966. doi: 10.1093/embo-reports/kvf191.
  130. Wada K, Inoue K, Hagiwara M. (2002) Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy. Biochim Biophys Acta. 1591(1-3):1-10. doi: 10.1016/s0167-4889(02)00202-1.
  131. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M. (2002) A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. J Biol Chem. 277(26):23909-23918. doi: 10.1074/jbc.M200837200.
  132. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M. (2002) Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J Biol Chem. 277(26):23919-23926. doi: 10.1074/jbc.M200838200.
  133. Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M. (2001) Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J Biol Chem. 276(40):37520-37528. doi: 10.1074/jbc.M106207200.
  134. Kojima T, Zama T, Wada K, Onogi H, Hagiwara M. (2001) Cloning of Human PRP4 Reveals Interaction with Clk1. Biol. Chem. 276, 32247-32256. doi: 10.1074/jbc.M103790200.
  135. Osada M, Inaba R, Shinohara H, Hagiwara M, Nakamura M, Ikawa Y. (2001) Regulatory domain of protein stability of human P51/TAP63, a P53 homologue. Biochem Biophys Res Commun. 283(5):1135-1141. doi: 10.1006/bbrc.2001.4905.
  136. Aratani S, Fujii R, Oishi T, Fujita H, Amano T, Ohshima T, Hagiwara M, Fukamizu A, Nakajima T. (2001) Dual roles of RNA helicase A in CREB-dependent transcription. Mol Cell Biol. 21(14):4460-4469. doi: 10.1128/MCB.21.14.4460-4469.2001.
  137. Ueda HR, Hagiwara M, Kitano H. (2001) Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J Theor Biol. 210(4):401-406. doi: 10.1006/jtbi.2000.2226.
  138. Kuroyanagi H, Kimura T, Wada K, Hisamoto N, Matsumoto K, Hagiwara M. (2000) SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development. Mech Dev. 99(1-2):51-64. doi: 10.1016/s0925-4773(00)00477-9.
  139. Muro Y, Kamimoto T, Tomita Y, Hagiwara M. (2000) Spectrum of autoantibodies against a dynamin-related protein, dymple. Arthritis Rheum. 43(7):1516-1519. doi: 10.1002/1529-0131(200007)43:7<1516::AID-ANR15>3.0.CO;2-Q.
  140. Inoue K, Mizuno T, Wada K, Hagiwara M. (2000) Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p. J Biol Chem. 275(42):32793-32799. doi: 10.1074/jbc.M004560200.
  141. Usukura J, Nishizawa Y, Shimomura A, Kobayashi K, Nagatsu T, Hagiwara M. (2000) Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy. Genes Cells. 5(6):515-522. doi: 10.1046/j.1365-2443.2000.00345.x.
  142. Nagai Y, Miyazaki M, Aoki R, Zama T, Inoue S, Hirose K, Iino M, Hagiwara M. (2000) A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat Biotechnol. 18(3):313-316. doi: 10.1038/73767.
  143. Kawahara K, Watanabe S, Ohshima T, Soejima Y, Oishi T, Aratani S, Nakata M, Shibata M, Inoue K, Amano T, Fujii R, Yanai K, Hagiwara M, Fukamizu A, Maruyama I, Nakajima T. (1999) Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells. Biochem Biophys Res Commun. 266(2):417-424. doi: 10.1006/bbrc.1999.1812.
  144. Sakaguchi H, Wada K, Maekawa M, Watsuji T, Hagiwara M. (1999) Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain. J Neurosci. 19(10):3973-3981. doi: 10.1523/JNEUROSCI.19-10-03973.1999.
  145. Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer A, Hagiwara M. (1999) The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem. 274(16):11125-1131. doi: 10.1074/jbc.274.16.11125.
  146. Okamoto Y, Onogi H, Honda R, Yasuda H, Wakabayashi T, Nimura Y, Hagiwara M. (1998) cdc2 kinase-mediated phosphorylation of splicing factor SF2/ASF. Biochem Biophys Res Commun. 249(3):872-878. doi: 10.1006/bbrc.1998.9247.
  147. Yoshida K, Imaki J, Okamoto Y, Iwakabe H, Fujisawa H, Matsuda A, Nakanishi S, Matsuda H, Hagiwara M. (1998) CREB-induced transcriptional activation depends on mGluR6 in rod bipolar cells. Mol Brain Res. 57(2):241-247. doi: 10.1016/s0169-328x(98)00089-8.
  148. Shimomura A, Okamoto Y, Hirata Y, Kobayashi M, Kawakami K, Kiuchi K, Wakabayashi T, Hagiwara M. (1998) Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells. J Neurochem. 70(3):1029-1034. doi: 10.1046/j.1471-4159.1998.70031029.x.
  149. Muro Y, Ogawa Y, Kato Y, Hagiwara M. (1998) Autoantibody to thioredoxin reductase in an ovarian cancer patient. Biochem Biophys Res Commun. 242(2):267-271. doi: 10.1006/bbrc.1997.7914.
  150. Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M. (1998) Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem Biophys Res Commun. 242(2):357-364. doi: 10.1006/bbrc.1997.7913.
  151. Kamimoto T, Nagai Y, Onogi H, Muro Y, Wakabayashi T, Hagiwara M. (1998) Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 273(2):1044-1051. doi: 10.1074/jbc.273.2.1044.
  152. Muro Y, Kano T, Sugiura K, Hagiwara M. (1997) Low frequency of autoantibodies against Ki-67 antigen in Japanese patients with systemic autoimmune diseases. J Autoimmun. 10(5):499-503. doi: 10.1006/jaut.1997.0157.
  153. Nomoto S, Watanabe Y, Ninomiya-Tsuji J, Yang LX, Kiuchi K, Hagiwara M, Hidaka H, Matsumoto K, Irie K. (1997) Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts. Genes Cells. 2(10):601-614. doi: 10.1046/j.1365-2443.1997.1470346.x.
  154. Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M. (1997) Identification of a novel nuclear speckle-type protein, SPOP. FEBS Lett. 418(1-2):23-26. doi: 10.1016/s0014-5793(97)01340-9.
  155. Masunaga R, Nagasaka A, Nakai A, Kotak M, Sawai Y, Oda N, Mokuno T, Shimazaki K, Hayakawa N, Kato R, Hiran E, Hagiwara M, Hidaka H. (1997) Alteration of platelet aggregation in patients with thyroid disorders. 46(10):1128-1131. doi: 10.1016/s0026-0495(97)90203-1.
  156. Watsuji T, Okamoto Y, Emi N, Katsuoka Y, Hagiwara M. (1997) Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system. Biochem Biophys Res Commun. 234(3):769-773. doi: 10.1006/bbrc.1997.6705.
  157. Watanabe Y, Takaetsu G, Hagiwara M, Irie K, Matsumoto K. (1997) Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol. 17(5):2615-2623. doi: 10.1128/MCB.17.5.2615.
  158. Sugiura K, Muro Y, Nagai Y, Hagiwara M. (1997) Expression cloning and intracellular localization of a human ZF5 homologue. Biochem Biophys Acta. 1352(1):23-26. doi: 10.1016/s0167-4781(97)00045-6.
  159. Muro Y, Kamimoto T, Hagiwara M. (1997) Anti-mitosin antibodies in a patient with chronic graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant. 19(9):951-3. doi: 10.1038/sj.bmt.1700764.
  160. Kobayashi M, Shimomura A, Hagiwara M, Kawakami K. (1997) Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter. Nucleic Acids Res. 25(4):877-882. doi: 10.1093/nar/25.4.877.
  161. Okajima T, Okuno S, Fujisawa H, Hagiwara M. (1996) Nuclear localization of Ca2+/Calmodulin-dependent protein kinase IV and calspermin. bioimages 4(3):117-128.org/10.11169/bioimages.4.117.
  162. Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K, Nishida E. (1996). Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. J Biol Chem. 271(43):26981-26988. doi: 10.1074/jbc.271.43.26981.
  163. Okada H, Miyamura K, Ito T, Hagiwara M, Wakabayashi T, Mizuno M, Colosi P, Kurtzman G, Yoshida J. (1996) Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Ther. 3(11):957-964.
  164. Shimomura A, Ogawa Y, Fujisawa H, Hagiwara M. (1996) Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein. J Biol Chem. 271(30):17957-17960. doi: 10.1074/jbc.271.30.17957.
  165. Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M. (1996) A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 271(23):13675-13679. doi: 10.1074/jbc.271.23.13675.
  166. Yasunami M, Suzuki K, Maruyama H, Kawakami H, Nagai Y, Hagiwara M, Ohkubo H. (1996) Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem Biophys Res Commun. 220(3):754-758. doi: 10.1006/bbrc.1996.0476.
  167. Okada H, Yoshida J, Sokabe M, Wakabayashi T, Hagiwara M. (1996) Suppression of CD44 expression decreases migration and invasion of human glioma cells. Int J Cancer. 66(2):255-260. doi: 10.1002/(SICI)1097-0215(19960410)66:2<255::AID-IJC20>3.0.CO;2-A.
  168. Yoshida K, Imaki J, Fujisawa H, Harada T, Ohki K, Matsuda H, Hagiwara M. (1996) Differential distribution of CaM kinases and induction of c-fos expression by flashing and sustained light in rat retinal cells. Invest Ophthalmol Vis Sci. 37(1):174-179.
  169. Harada T, Imaki J, Hagiwara M, Ohki K, Takamura M, Ohashi T, Matsuda H, Yoshida K. (1995) Phosphorylation of CREB in rat retinal cells after focal retinal injury. Exp Eye Res. 61(6):769-772. doi: 10.1016/s0014-4835(05)80030-2.
  170. Kano T, Suzuki Y, Shibuya M, Kiuchi K, Hagiwara M. (1995) Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. Neuroreport. 6(16):2197-2200. doi: 10.1097/00001756-199511000-00023.
  171. Ohki K, Yoshida K, Hagiwara M, Harada T, Takamura M, Ohashi T, Matsuda H, Imaki J. (1995) Nitric oxide induces c-fos gene expression via cyclic AMP response element binding protein (CREB) phosphorylation in rat retinal pigment epithelium. Brain Res. 696(1-2):140-144. doi: 10.1016/0006-8993(95)00914-c.
  172. Yoshida K, Imaki J, Matsuda H, Hagiwara M. (1995) Light-induced CREB phosphorylation and gene expression in rat retinal cells. J Neurochem. 65(4):1499-1504. doi: 10.1046/j.1471-4159.1995.65041499.x.
  173. Okada H, Yoshida J, Seo H, Wakabayashi T, Sugita K, Hagiwara M. (1994) Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells. Cancer Immunol Immunother. 9(5):313-317. doi: 10.1007/BF01519984.
  174. Matsushima H, Shimohama S, Tanaka S, Taniguchi T, Hagiwara M, Hidaka H, Kimura J. (1994) Platelet protein kinase C levels in Alzheimer’s disease. Neurobiol Aging. 15(6):671-674. doi: 10.1016/0197-4580(94)90047-7.
  175. Alberts AS, Arias J, Hagiwara M, Montminy MR, Feramisco JR. (1994) Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J Biol Chem. 269(10):7623-7630.
  176. Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy RM, Goodman RH. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 365(6449):855-859. doi: 10.1038/365855a0.
  177. Nakamura S, Wakusawa S, Tajima K, Miyamoto K, Hagiwara M, Hidaka H. (1993) Effects of isoquinolinesulphonamide compounds on multidrug-resistant P388 cells. J Pharm Pharmacol. 45(4):268-273. doi: 10.1111/j.2042-7158.1993.tb05551.x.
  178. Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H, Taniguchi T. (1993) Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer’s disease. Neurology. 43(7):1407-1413. doi: 10.1212/wnl.43.7.1407.
  179. Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy RM. (1993) Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol. 13(8):4852-4859. doi: 10.1128/mcb.13.8.4852-4859.1993.
  180. Kawamoto F, Fujioka H, Murakami R, Syafruddin, Hagiwara M, Ishikawa T, Hidaka H. (1993) The roles of Ca2+/calmodulin- and cGMP-dependent pathways in gametogenesis of a rodent malaria parasite, Plasmodium berghei. Eur J Cell Biol. 60(1):101-107.
  181. Matsushima H, Shimohama S, Yamaoka Y, Kimura J, Taniguchi T, Hagiwara M, Hidaka H. (1993) Alteration of human platelet protein kinase C with normal aging. Mech Ageing Dev. 69(1-2):129-136. doi: 10.1016/0047-6374(93)90077-5.
  182. Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M. (1992) Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell. 70(1):105-113. doi: 10.1016/0092-8674(92)90537-m.
  183. Okazaki K, Watanabe M, Ando Y, Hagiwara M, Terasawa M, Hidaka H. (1992) Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Biochem Biophys Res Commun. 185(1):147-153. doi: 10.1016/s0006-291x(05)80968-4.
  184. Goto S, Kobayashi M, Murate T, Hotta T, Hagiwara M, Hoshino T, Hidaka H, Saito H. (1992). Thrombin-induced shape change in human megakaryoblastic leukemic cells, MEG-01, is mediated by protein kinase C. Thromb Res. 68(1):87-95. doi: 10.1016/0049-3848(92)90130-3.
  185. Usuda N, Hagiwara M, Kong Y, Shimizu T, Hidaka H, Nagata T. (1992) Immunohistochemical locazilation of protein kinase C isozymes. Acta Histochem Cytochem. 25(6):707-715.
  186. Wakusawa S, Nakamura S, Tajima K, Miyamoto K.-I, Hagiwara M, Hidaka, H. (1992) Overcoming of vinblastine resistance by isoquinolinesulfonamide compounds in adriamycin-resistant leukemia cells. Mol Pharmacol. 41(6):1034-1038.
  187. Kato M, Hagiwara M, Hidaka H. (1992) Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay (RBA). Biochem J. 281(2):339-342. doi: 10.1042/bj2810339.
  188. Iwamoto T, Hagiwara M, Hidaka H, Isomura T, Kioussis D, Nakashima I. (1992) Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J Biol Chem. 267(26):18644-18648.
  189. Uchida C, Hagiwara M, Hidaka H. (1991) Ca(2+)-independent, phospholipid-activated protein kinase in 3Y1 cells. Arch Biochem Biophys. 288(2):421-426. doi: 10.1016/0003-9861(91)90215-5.
  190. Terasawa M, Hagiwara M, Hachiya T, Kobayashi R, Obata S, Wakabayashi T, Hidaka H. (1991) Identification and characterization of protein kinase C-related enzymes in frog retina. Arch Biochem Biophys. 287(2):213-217. doi: 10.1016/0003-9861(91)90409-c.
  191. Hagiwara M, Wakusawa S, Miyamoto K, Hidaka H. (1991) Obviation of drug resistance and affinity purification of P-glycoprotein by isoquinolinesulfonamides. Cancer Lett. 60(2):103-107. doi: 10.1016/0304-3835(91)90215-4.
  192. Sumi M, Kiuchi K, Ishikawa T, Ishii A, Hagiwara M, Nagatsu T, Hidaka H. (1991) The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 181(3):968-975. doi: 10.1016/0006-291x(91)92031-e.
  193. Shimizu T, Usuda N, Sugenoya A, Masuda H, Hagiwara M, Hidaka H, Nagata T, Iida F. (1991) Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. Cell Mol Biol. 37(8):813-821.
  194. Usuda N, Kong Y, Hagiwara M, Uchida C, Terasawa M, Nagata T, Hidaka H. (1991) Differential localization of protein kinase C isozymes in retinal neurons. J Cell Biol. 112(6):1241-1247. doi: 10.1083/jcb.112.6.1241.
  195. Kato M, Hagiwara M, Nimura Y, Shionoya S, Hidaka H. (1991) Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands. J Endocrinol. 131(1):155-162. doi: 10.1677/joe.0.1310155.
  196. Koyama Y, Fukaya Y, Ueda H, Hachiya T, Hagiwara M, Hidaka H, Marunouchi T. (1990) Expression of protein kinase C isozyme in human Langerhans’ cell. Acta Derm Venereol. 70(6):502-505.
  197. Koyama Y, Hachiya T, Hagiwara M, Kobayashi M, Ohashi K, Hoshino T, Hidaka H, Marunouchi T. (1990) Expression of protein kinase C isozyme in epidermal Langerhans cells of the mouse. J Invest Dermatol. 94(5):677-680. doi: 10.1111/1523-1747.ep12876255.
  198. Onoda K, Hagiwara M, Hachiya T, Usuda N, Nagata T, Hidaka H. (1990) Different expression of protein kinase C isozymes in pancreatic islet cells. Endocrinology. 126(2):1235-1240. doi: 10.1210/endo-126-2-1235.
  199. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, Hidaka H. (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem. 265(9):5267-5272.
  200. Miyamoto K, Wakusawa S, Nakamura S, Koshiura R, Otsuka K, Naito K, Hagiwara M, Hidaka, H. (1990) Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87. Cancer Lett. 51(1):37-42. doi: 10.1016/0304-3835(90)90228-p.
  201. Hachiya T, Hagiwara M, Hidaka H. (1990) Immunoaffinity purification of type I protein kinase C. Arch Biochem Biophys. 280(2):358-361. doi: 10.1016/0003-9861(90)90342-v.
  202. Sumi M, Hagiwara M, Hidaka H. (1990) d-Indobufen inhibits collagen-induced intracellular calcium mobilization and inositol phosphates formation in human platelets. Thromb Res. 59(2):319-326. doi: 10.1016/0049-3848(90)90134-x.
  203. Shimosawa S, Hachiya T, Hagiwara M, Usuda N, Sugita K, Hidaka H. (1990) Type-specific expression of protein kinase C isozymes in CNS tumor cells. Neurosci Lett. 108(1-2):11-16. doi: 10.1016/0304-3940(90)90698-9.
  204. Hagiwara M, Uchida C, Usuda N, Nagata T, Hidaka H. (1990) zeta-Related protein kinase C in nuclei of nerve cells. Biochem Biophys Res Commun. 168(1):161-168. doi: 10.1016/0006-291x(90)91688-o.
  205. Hagiwara M, Hachiya T, Watanabe M, Usuda N, Iida F, Tamai K, Hidaka H. (1990) Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. Cancer Res. 50(17):5515-5519.
  206. Hagiwara M, Sumi M, Usuda N, Nagata T, Hidaka H. (1990) Discrepancy of protein kinase C translocation and platelet aggregation―immunocytobiochemical evidence. Arch Biochem Biophys. 280(1):201-205. doi: 10.1016/0003-9861(90)90536-8.
  207. Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H. (1990). KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J Biol Chem. 265(8):4315-4320.
  208. Watanabe M, Hachiya T, Hagiwara M, Hidaka H. (1989) Identification of type III protein kinase C in bovine aortic tissue. Arch Biochem Biophys. 273(1):165-169. doi: 10.1016/0003-9861(89)90175-6.
  209. Mamiya S, Hagiwara M, Ishikawa T, Hidaka H. (1989) Specific inhibition of 40 K protein phosphorylation in platelet by a new antithrombotic agent, d-indobufen. Thromb Res. 54(5):447-456. doi: 10.1016/0049-3848(89)90214-4.
  210. Mamiya S, Hagiwara M, Inoue S, Hidaka H. (1989) Thyroid hormones inhibit platelet function and myosin light chain kinase. J Biol Chem. 264(15):8575-8579.
  211. Kariya K, Kawahara Y, Fukuzaki H, Hagiwara M, Hidaka H, Fukumoto Y, Takai, Y. (1989) Two types of protein kinase C with different functions in cultured rabbit aortic smooth muscle cells. Biochem Biophys Res Commun. 161(3):1020-1027. doi: 10.1016/0006-291x(89)91345-4.
  212. Tokumitsu H, Hagiwara M, Onoda K, Hidaka H. (1989) Anti-gizzard MLCK monoclonal antibody MM13 inhibits superprecipitation and phosphorylation of bovine aortic smooth muscle actomyosin. J Biochem. 106(3):511-514. doi: 10.1093/oxfordjournals.jbchem.a122883.
  213. Chijiwa T, Hagiwara M, Hidaka H. (1989) A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J Biol Chem. 264(9):4924-4927.
  214. Fu T, Okano Y, Hagiwara M, Hidaka H, Nozawa Y. (1989) Bradykinin-induced translocation of protein kinases C in neuroblastoma NCB-20 cell: dependence on 1,2-diacylglycerol content and free calcium. Biochem Biophys Res Commun. 162(3):1279-1286. doi: 10.1016/0006-291x(89)90812-7.
  215. Hagiwara M, Tokumitsu H, Onoda K, Tanaka T, Ito M, Kato N, Hidaka H. (1989) Monoclonal antibody assessment of tissue- and species-specific myosin light chain kinase isozymes. J Biochem. 106(1):71-75. doi: 10.1093/oxfordjournals.jbchem.a122822.
  216. Hagiwara M, Mamiya S, Hidaka H. (1989) Selective binding of L-thyroxine by myosin light chain kinase. J Biol Chem. 264(1):40-44.
  217. Ishikawa T, Chijiwa T, Hagiwara M, Mamiya S, Hidaka H. (1989) Thyroid hormones directly interact with vascular smooth muscle strips. Mol Pharmacol. 35(6):760-765.
  218. Tanaka T, Hagiwara M, Hidaka H, Nunoki K, Ohta H, Onoda K, Ito M, Ohkubo S, Hiai H, Nishizuka Y. (1989) Selective low level of protein kinase C isozyme in a tumor promoter-dependent mouse leukemia cell line. Biochem Biophys Res Commun. 164(3):1397-1401. doi: 10.1016/0006-291x(89)91825-1.
  219. Abougou JC, Hagiwara M, Hachiya T, Terasawa M, Hidaka H, Hartshorne DJ. (1989) Phosphorylation of caldesmon. FEBS Lett. 257(2):408-410. doi: 10.1016/0014-5793(89)81583-2.
  220. Hagiwara M, Mamiya S, Ochiai M, Hidaka H. (1988) Thyroid hormones inhibit the Ca2+ calmodulin-induced activation of myosin light chain kinase. Biochem Biophys Res Commun. 152(1):270-276. doi: 10.1016/s0006-291x(88)80710-1.
  221. Hagiwara M, Inagaki M, Takahashi J, Yoshida T, Hidaka H. (1988) A fluorescent protein kinase C inhibitor: 1-(1-hydroxy-5-isoquinolinylsulfonyl)piperazine. Pharmacology. 36(6):365-370. doi: 10.1159/000138324.
  222. Ishikawa T, Chijiwa T, Hagiwara M, Mamiya S, Saitoh M, Hidaka H. (1988) ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. Mol Pharmacol. 33(6):598-603
  223. Hagiwara M, Inagaki M, Kanamura K, Ohta H, Hidaka H. (1988) Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C. J Pharmacol Exp Ther. 244(1):355-360.
  224. Kiuchi K, Hagiwara M, Hidaka H, Nagatsu T. (1988) Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells. Neurosci Lett. 89(2):209-215. doi: 10.1016/0304-3940(88)90383-7.
  225. Ito T, Tanaka T, Yoshida T, Onoda K, Ohta H, Hagiwara M, Itoh Y, Ogura M, Saito H, Hidaka H. (1988) Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association. J Cell Biol. 107(3):929-937. doi: 10.1083/jcb.107.3.929.
  226. Hagiwara M, Ochiai M, Owada K, Tanaka T, Hidaka H. (1988) Modulation of tyrosine phosphorylation of p36 and other substrates by the S-100 protein. J Biol Chem. 263(13):6438-6441.
  227. Hagiwara M, Inoue S, Tanaka T, Nunoki K, Ito M, Hidaka H. (1988) Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. Biochem Pharmacol. 37(15):2987-2992. doi: 10.1016/0006-2952(88)90286-9.
  228. Tanaka T, Ishikawa T, Hagiwara M, Onoda K, Itoh H, Hidaka H. (1988) Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle. Pharmacology. 36(5):313-320. doi: 10.1159/000138400.
  229. Hidaka H, Tanaka T, Onoda K, Hagiwara M, Watanabe M, Ohta H, Ito Y, Tsurudome M, Yoshida T. (1988). Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum. J Biol Chem. 263(10):4523-4526.
  230. Watanabe M, Hagiwara M, Onoda K, Hidaka H. (1988). Monoclonal antibody recognition of two subtype forms of protein kinase C in human platelets. Biochem Biophys Res Commun. 52(2):642-648. doi: 10.1016/s0006-291x(88)80087-1.
  231. Hagiwara M, Inagaki M, Watanabe M, Ito M, Onoda K, Tanaka T, Hidaka H. (1987) Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 32(1):7-12
  232. Hagiwara M, Inagaki M, Hidaka H. (1987) Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase. Mol Pharmacol. 31(5):523-528.
  233. Inagaki M, Hagiwara M, Saitoh M, Hidaka H. (1986) Protein kinase C negatively modulated by phorbol ester. FEBS Lett. 202(2):277-281. doi: 10.1016/0014-5793(86)80701-3.
  234. Inagaki M, Kawamoto S, Itoh H, Saitoh M, Hagiwara M, Takahashi J, Hidaka H. (1986) Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 29(6):577-581.
  235. Hagiwara M, Endo T, Kanayama T, Hidaka H. (1984) Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J Pharmacol Exp Ther. 228(2):467-471.
  236. Hagiwara M, Endo T, Hidaka H. (1984) Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem Pharmacol. 33(3):453-457. doi: 10.1016/0006-2952(84)90240-5.